"Real English 20-wreak havoc"

Last week a tornado wreaked havoc in Ibaraki, Tochigi Prefecture.
Yes, you heard me right. Don't doubt your ears!  A tornado in Japan!!  Tornadoes are extremely rare in Japan, but recently Mother Nature is strange...


Last month, I had a skin problem on my foot, so I went to the drug store and got some "special cream."  I heard that this "special cream" would cure my ailment.  But, to my surprise, the "special cream" wreaked havoc on my foot, and made the problem even worse.


In the NBA, my team the Philadelphia 76ers is in the playoffs now.  I hope they wreak havoc on the court.


Here are some other ways we use this expression:
Big trucks with all the pollution they create really wreak havoc on the environment.
The new virus wreaked havoc on computer networks all over the world.


From the context of the sentences above, can you understand the meaning of "wreak havoc"?
Basically, "wreak havoc" means to "damage," "hurt," "cause serious damage/pain."